Rin detergent is a surfactant or a mixture of surfactants with cleansing properties in dilute solutions. It is cleaning all the types of clothes. These substances are usually alkylbenzene sulfonates , a family of compounds that are similar to soap but are more soluble in hard water , because the polar sulfonate (of detergents) is less likely than the polar carboxylate (of soap) to bind to calcium and other ions found in hard water. Detergents are used for the solubilization of integral membrane proteins and for keeping them in solution during subsequent purification procedures [2,3,8], but it is impossible to predict how any particular protein will respond to any particular detergent. These substances are also known as tensides, soluble amphiphiles, soaps and surface active agents.